Introduction Advancements in technology and cardiovascular management with timely coronary revascularization have improved the survival rate of patients with myocardial infarction. Secondary prevention strategies such as lifestyle modification, drug therapy, and cardiac rehabilitation are essential in improving patient outcomes. Thus, patients need to adhere to modifying risk factors to prevent the recurrence of a cardiovascular event. Accordingly, this study aims to determine patients’ adherence to coronary artery disease risk factors modification post-myocardial infarction and examine the relationships between the level of adherence and sociodemographic variables.

Methods A cross-sectional study was conducted to measure the level of adherence to risk factor modification among patients six months post-myocardial infarction. A Chi-square test was employed to determine the significant relationships between sociodemographic variables and the level of adherence to risk factor modification.

Results Out of the total of 227 respondents, 128 (56.4%) were reported to have good adherence. Adherence was good in terms of medication but poor in terms of smoking cessation, healthy diet, exercise, and psychosocial management. There were significant associations between adherence to risk factor modification and age (p = 0.000), gender (p = 0.040), and education level (p = 0.003).

Discussion The result of this study is comparable to most previous studies. However, non-adherence to healthy lifestyles such as smoking cessation, healthy diet, exercise, and psychosocial management is concerning. This suggests the need for more effective health education programs. Eligible patients should be enrolled in cardiac rehabilitation programs to assist them in healthy lifestyle practices.

Conclusion This study revealed that 43.6% of the respondents exhibit poor adherence to risk factor modification for cardiovascular disease. Thus, effective health education and support programs are essential to increase adherence, improve patient outcomes, and lower the risk of recurring cardiac events. In addition, interventional studies to enhance patients’ adherence to healthy lifestyles must be considered.